From crime-fighting agents to vampire slaying teenagers, these feisty and fearless females have provided hours of telly box entertainment. Some of them are calculating leaders and others are quiet professionals who know how to strike at just the right moment.
We've watched Christina Yang and considered going back to uni to be a surgeon and we've watched as Peggy Olsen fought back against her chauvinistic colleagues to become a copywriter. Talk about inspiring!
Take a look at our pick of the top 15 most powerful female characters on TV in the gallery below...
What do you think? Have we missed anyone crucial?
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