She plays an egocentric talk show host who knows nothing about parenthood in the television series Up All Night but in reality Maya Rudolph a very experienced mother and is about to add to her existing brood.
The actress is believed to be expecting her fourth child with writer and director Paul Thomas Andersen.
Sources have confirmed that Maya has told executives on her NBC show she is pregnant.
The news places a question mark over the future of the television series after Christina Applegate's exit from the show last week.
'Up All Night' follows the trials and tribulations of parenthood as Christina Applegate's character struggles with being a stay-at-home mum.
According to The Hollywood Reporter, the show's writers had initially planned to incorporate Rudolph's pregnancy into the storyline, but with Applegate gone, the series may be cancelled.
The 40-year-old comedic actress already has three children with filmmaker Andersen: Pearl, 7, Lucille, 3, and Jack, 19 months.
She told LimeLife: 'I'm a little bit of a pro now. The stuff that I use to fear and worry about is so different now.'
She said that bringing her first baby home from the hospital was stressful, but by the third child, 'We didn't even have a car seat anymore, and when we finally got one we didn't even install it properly because we were just running out of the hospital. We just wanted to get home. I even ended up just driving myself!'
For more information on pregnancy health and advice go to www.nhs.uk/Start4Life